2001

  • M.J. Kogan, I. Dalcol, P. Gorostiza, C. López-Iglesias, M. Pons, F. Sanz, D. Ludevid and E. Giralt.
    Self-assembly of the Amphipathic Helix (VHLPPP)8. A Mechanism for Zein Protein Body Formation. J. Mol. Biol., 312, 907-913 (2001).
  • F. Cárdenas, M. Thormann, M. Feliz, J. M Caba, P. Lloyd-Williams and E. Giralt.
    Conformational Analysis of Dehydrodidemnin B (Aplidine) by NMR Spectroscopy and Molecular Mechanics/Dynamics Calculations. J. Org. Chem., 66, 4580-4584 (2001).
  • P. Lloyd-Williams and E. Giralt.
    Antropisomerism, biphenyls and the Suzuki coupling: peptide antibiotics. Chem. Soc. Rev., 30, 145-157 (2001).
  • R. Marchetto, E. Nicolás, N. Castillo, J. Bacardit, M. Navia, J. Vila and E. Giralt.
    Two Short Peptides Including Segments of Subunit A of Escherichia coli DNA Gyrase as Potential Probes to Evaluate the Antibacterial Activity of Quinolones. J. Peptide Sci., 7, 27-40 (2001).
  • J. Piro, M. Rubiralta, E.Giralt and A. Diez.
    Solid phase synthesis of enantiomerically pure polyhydroxyvalerolactams. Tetrahedron Lett., 42, 871-873 (2001).
  • L. Taboada, E. Nicolás and E. Giralt.
    One-pot full peptide deprotection in Fmoc-based solid-phase peptide synthesis: methionine sulfoxide reduction with Bu4NBr. Tetrahedron Lett., 42, 1891-1893 (2001).
  • F. Albericio, M. Cruz, L. Debéthune, R. Eritja, E. Giralt, A. Grandas, V. Marchán, J. Pastor, E. Pedroso, F. Rabanal and M. Royo.
    An improved synthesis on N-[9-hydroxymethyl)-2-Fluorenyl]succinamic acid (HMFS), a versatile handle for the solid-phase synthesis of biomolecules. Synthetic Communications, 31, 225-232 (2001).
  • M. Royo, J. Jiménez, A. Lopez, E.Giralt and F. Albericio.
    Solid-Phase Synthesis of Peptides Containing a, b-Didehydroamino Acids. Eur. J. Org. Chem., 45-48 (2001).
  • P. Gomes, E. Giralt and D. Andreu.
    Antigenicity modulation upon peptide cyclization: application to the GH loop of foot-and-mouth disease virus strain C1-Barcelona. Vaccine, 19, 3459-3466 (2001).
  • A. Codina, M. Vilaseca, T. Tarragó, I. Fernández, D. Ludevid and E. Giralt.
    Location of Disulfide Bonds in Mature a-L-Fucosidase from Pea. J. Peptide Sci., 7, 305-315 (2001).
  • A. Codina, I. Fernández, I. Martínez, D. Ludevid and E. Giralt.
    Combined use of ESI-MS and UV diode-array detection for localization of disulfide bonds in proteins: application to an a-L-fucosidase of pea. J. Peptide Res., 57, 473-482 (2001).
  • A. López-Macià, J. C. Jiménez, M. Royo, E. Giralt and F. Albericio.
    Synthesis and Structure Determination of Kahalalide F. J. Am. Chem. Soc., 123, 11398-11401 (2001).
  • B. Bahbouhi, M. Bendjennat, C. Chiva, M. Kogan, F. Albericio, E. Giralt, N. Georges Seidah and E. Bahraoui.
    Inhibition of HIV-2ROD replication in a lymphoblastoid cell line by the a1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1LAI. Microbes and Infection, 3, 1073-1084 (2001).
  • J. M. Caba, I. M. Rodríguez, I. Manzanares, E. Giralt and F. Albericio.
    Solid-Phase Total Synthesis of Trunkamide A. J. Org. Chem., 66, 7568-7574 (2001).
  • J. Villén, E. Borràs, W. M. M. Schaaper, R. H. Meloen, M. Dávila, E. Domingo, E. Giralt and D. Andreu. Synthetic Peptides as Functional Mimics of a Viral Discontinuous Antigenic Site. Biologicals,29, 265-269 (2001)

2002

  • J. Villén, E. Borras, W. M. M. Schaaper, R. H. Meloen, M. Dávila, E. Domingo, E. Giralt and D. Andreu. Functional mimicry of a discontinuous antigenic site by a designed synthetic peptide. Chem. BioChem., 3, 175-182 (2002).
  • M. M. Fernández, A. Diez, M. Rubiralta, E. Montenegro, N. Casamitjana, M. J. Kogan and E. Giralt. Spirolactams as Conformationally Restricted Pseudopeptides: Synthesis and Conformational Analysis. J. Org. Chem., 67, 7587-7599 (2002).
  • B. Orner, X. Salvatella, J. Sánchez-Quesada, J. de Mendoza, E. Giralt and A. D. Hamilton.
    De Novo Protein Surface Design: Use of Cation-p Interactions to Enhance Binding between an a-Helical Peptide and a Cationic Molecule in 50% Aqueous Solution. Angew. Chem., 41, 117-119 (2002).
  • L. Crespo, G. Sanclimens, M. Royo, E. Giralt and F. Albericio.
    Branched poly(proline) peptides: an efficient new approach to the synthesis of repetitive branched peptides. Eur. J. Org. Chem., 11, 1756-1762 (2002).
  • B. Bahbouhi, N. Chazal, N.G. Seidah, C. Chiva, M. Kogan, F. Albericio, E. Giralt and E. Bahraoui.
    Effects of I-and d-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication. Biochem. J., 366, 863-872 (2002).
  • M. Kogan, I. Dalcol, P. Gorostiza, C. López-Iglesias, R. Pons, M. Pons, F. Sanz and E. Giralt. Supramolecular properties of the proline-rich gamma-zein N-terminal domain. Biophys. J., 83, 1194-1204 (2002).
  • L. Crespo, G. Sanclimens, B. Montaner, R. Pérez-Tomás, M. Royo, M. Pons and F. Albericio, E. Giralt. Peptide Dendrimers Based on Polyproline Helices. J. Am. Chem. Soc., 124, 8876-8883 (2002).
  • A. Codina, M. Gairí, T. Tarragó, A.R. Vigueras, M. Feliz, D. Ludevid and E. Giralt.
    1H(N), 15N, 13CO, 13C assignment and secondary structure of a 20 kDa a-L-fucosidade from pea using TROSY. J. Biomol. NMR, 22, 295-296 (2002).
  • P. Gomes, E. Giralt, W. Ochoa, N. Verdaguer and D. Andreu.
    Probing degeneracy in antigen-antibody recognition at the immunodominant site of foot-and-mouth disease virus. J. Peptide Res., 59, 221-231 (2002).
  • D. Fernández-Forner, J. M. Huerta, M. Ferrer, G. Casals, H. Ryder, E. Giralt and F. Albericio.
    Solid-phase syntheses of N-substituted carbamates. Reaction monitoring by gel-phase 13C NMR using a 13C enriched BAL-linker. Tetrahedron Letters, 43, 3543-3546 (2002).
  • J. J. Pastor, I. Fernández, F. Rabanal and E. Giralt.
    A New Method for the Preparation of Unprotected Peptides on Biocompatible Resins with Application in Combinatorial Chemistry. Org. Letters, 4, 3831-3833 (2002).
  • F. Rabanal, J. M. Tusell, Ll. Sastre, M. R. Quintero, M. Cruz, D. Grillo, M. Pons, F. Albericio and E. Giralt. Structural, Kinetic and Cytotoxicity Aspects of 12-28 b-Amyloid Protein Fragment: A Reappraisal. J. Peptide Sci., 8, 578-588 (2002).

2003

  • X. Salvatella, J. M. Caba, F. Albericio and E. Giralt.
    Solution Structure of the Antitumor Candidate Trunkamide A by 2D NMR and Restrained Simulated Annealing Methods. J. Org. Chem., 68, 211-215 (2003).
  • P. Forns, J. Piró, C. Cuevas, M. García, M. Rubiralta, E. Giralt and A. Diez.
    Constrained derivatives of stylostatin 1.1. Synthesis and biological evaluation as potencial anticancer agents. J. Med. Chem (2003), in press
  • C. Chiva, P. Barthe, A. Codina, M. Gairí, F. Molina, C. Granier, M. Pugniere, T. Inui, H. Nishi, Y. Nishiuchi, T. Kimura, S. Sakakibara, F. Albericio and E. Giralt.
    Synthesis and NMR Structure of P41icf, a Potent Inhibitor of Human Cathepsin L. J. Am. Chem. Soc., 125, 1508-1517 (2003).
  • F. Cardenas, J.M. Caba, M. Feliz, P. Lloyd-Williams and E. Giralt.
    Analisis of conformational equilibria in Aplidine using selective excitation 2D NMR Spectroscopy and molecular mechanics/dynamics calculations. J. Org. Chem., (2003), in press
  • M. Ecija, A. Diez, M. Rubiralta, N. Casamitjana, M. Kogan and E. Giralt.
    Síntesis of 3-aminolactams as X-Gly constrained pseudodipeptides and conformational study of a Trp-Gly surrogate. J. Org. Chem, (2003), in press
  • P. Lloyd-Williams, E. Giralt.
    Desymmetrization of the tetrahedron: stereogenic centres. J. Chem. Edu. 80 (10), 1178-1179 (2003).
  • M. Teixidó, M. Altamira, L. Quartara, A. Giolitti, C.A. Maggi, E. Giralt and F. Albericio.
    Byciclic homodetic peptide libraries: comparison of synthetic strategies for their solid-phase síntesis. J. Comb. Chem, 5 (6), 760-768 (2003).
  • X. Salvatella, E. Giralt.
    NMR-based methods and strategies for drug discovery. Chem. Soc. Rev., 32 (6), 365-372 (2003).
  • M. Teixidó, I. Belda, X. Roselló, S. González, M. Fabre, X. Llora, J. Bacardit, J.M. Garrell, S. Vilaró, F. Albericio and E. Giralt.
    Development of a genetic algorithm to design and identify peptides than can cross the blood-brain barrier: 1. Design and validation in silico. QSAR & Combinatorial Science, 22 (7), 745 (2003).
  • J. C. Jiménez, N. Bayo, B. Chavarria, A. Lopez-Macia, M. Royo, E. Nicolas, E. Giralt and F.Albericio. Synthesis of peptides containing a,b-didehydroamino acids. Scope and limitations. Lett. in Pept. Sci., 9, 135-141 (2003).
  • J. C. Jiménez, B. Chavarria, A. Lopez-Macia, M. Royo, E. Giralt and F.Albericio.
    Tentoxin as a Scaffold for Drug Discovery. Total Solid-Phase Synthesis of Tentoxin and a Library of Analogues. Organic Lett., 5, 2115-2118 (2003).
  • T. Tarragó, I. Martínez, M. Torrent, A. Codina, E. Giralt, P. Puigdomenech and D. Ludevid.
    The fuc1 gene product (20 kDa FUC1) of Pisum Sativum has no a-L-fucosidase activity. Plant Mol. Biol., 51, 877-884 (2003).
  • E. de Oliveira, J. Villén, E. Giralt and D. Andreu.
    Synthetic Approaches to Multivalent Lipopeptide Dendrimers Containing Disulfide Epitopes of Foot-and-Mouth Disease Virus. Bioconjugate Chem., 14, 144-152 (2003).
  • G. Sanclimens, L. Crespo, M. Pons, E. Giralt, F. Albericio and M. Royo.
    Saturated resins or stress of the resin. Tetrahedron Letters, 44, 1751-1754 (2003).
  • C. Escolano, M. J. Kogan, M. Rubiralta, E. Giralt and A. Diez.
    Spectral Assignments and Reference Data. Complete 1H and 13C NMR chemical shift assignment of N1-and N3-alkylnitrohistidines and of 1, 4, 6, 7-tetrahydroimidazo[4, 5-b]pyridines. Magn. Reson. Chem., 41, 219-222 (2003).