Our main interest is the design and synthesis of peptide molecules that are able to recognize specific hot-spots at protein surfaces. We use this knowledge to modulate protein-protein interactions. Furthermore, we have the know-how required to design and synthesize peptides able to modulate these recognition events either permanently or in response to light. We are also highly interested in unveiling the relevance of protein dynamics in the molecular recognition events that take place at protein surfaces. The methodological tools that we use for all these purposes are: computational methods, combinatorial chemistry, high-field NMR and mass-spectrometry.